We are the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF). We are a team of doctors, nurses, scientists and researchers who are dedicated to the improvement of the general health of children with CF.
We have two centres, one in Perth (Princess Margaret Hospital for Children) and one in Melbourne (Royal Children's Hospital).
Importantly, if you want to discuss any aspect of our research OR have a research idea, speak to a team member about this - we want to make your idea a reality.
Characterising low attenuation regions (LAR) on CT scans in children with cystic fibrosis
Repurpose and validate the use of a novel quantitative CT scoring technique (PRAGMA-CF) in MRI images. Using a mathematical model of the lung, assess how the extent and geographic distribution of CT LARs change over time and correlate these findings with clinical markers of disease.Determine the cause of CT LARs (ventilation, perfusion or combined defect) using functional MRI.
The development of personalised molecular therapies to treat disorders of surfactant protein metabolism
My affiliation with AREST CF comes from my research assistant position, which is now only part time. I work with Andre, Anthony and Steve on research studies focused on CF airway biology.
I am a masters medicine student from Rotterdam (Erasmus Medical Centre) in the Netherlands. I am doing my master's research project in Melbourne (RCH), which officialy lasts 5 months, but depending on the outcome of my study I will probably spend more time on it in the Netherlands as well. My supervisor here is Sarath Ranganathan.
The project focuses on the importance of early lung disease in cystic fibrosis. We are looking at children aged three months and one and three years of age between 2006-2015. We divided this into cohort 1 (2006-2010) and cohort 2 (2011-2015). We plan to look if there is a significant change in any of our variables. Our most important outcome is a possible change in proportion of patients with detectable free neutrophil elastase in BAL. Other outcomes include, lung function, MBW, CT-score changes, infection rates and proportion of patients who get admitted for IV-antibiotics.
Contact-email is either: email@example.com or firstname.lastname@example.org.
The aim of my research is to identify epigenetic markers from early life which predict the severity of lung disease at 9 years of age. I will do this by comparing two groups, one with mild lung disease and one with severe lung disease at 9 years of age (based on CT scan results), and I will perform whole genome methylation analysis on broncho-alveolar lavage from early life with the aim of indentifying differential methylation patterns between the two groups.
The study invovles patients with CF - so the 2 groups of kids will be kids with CF from the AREST CF cohort.